منابع مشابه
mRNAs scan themselves out
In eukaryotic cells, mRNAs are transcribed in the nucleus and must then be exported across the nuclear envelope before they can be translated in the cytoplasm. Multiple factors bind to nuclear mRNAs and mediate their translocation through the nuclear pores, but it is diffi cult to observe the rapid export of individual RNA molecules in real time. Two papers now track the movements of single mRN...
متن کاملSequestration of Highly Expressed mRNAs in Cytoplasmic Granules, P-Bodies, and Stress Granules Enhances Cell Viability
Transcriptome analyses indicate that a core 10%-15% of the yeast genome is modulated by a variety of different stresses. However, not all the induced genes undergo translation, and null mutants of many induced genes do not show elevated sensitivity to the particular stress. Elucidation of the RNA lifecycle reveals accumulation of non-translating mRNAs in cytoplasmic granules, P-bodies, and stre...
متن کاملThe EGP at five years.
Background: Mental distress among medical students is often reported. Burnout has not been studied frequently and studies using interviewer-rated diagnoses as outcomes are rarely employed. The objective of this prospective study of medical students was to examine clinically significant psychiatric morbidity and burnout at 3rd year of medical school, considering personality and study conditions ...
متن کاملStress management for mRNAs
A n enzyme involved in mRNA degradation turns into a transcript stabilizer during stress, Yoon et al. report. mRNA fates are determined by their association with regulatory proteins in ribonucleoprotein (mRNP) complexes. mRNPs can accumulate in large, cytosolic aggregates; P bodies, for example, contain translationally repressed mRNAs complexed with proteins that initiate mRNA destruction. One ...
متن کاملContext-dependent deposition and regulation of mRNAs in P-bodies
Cells respond to stress by remodeling their transcriptome through transcription and degradation. Xrn1p-dependent degradation in P-bodies is the most prevalent decay pathway, yet, P-bodies may facilitate not only decay, but also act as a storage compartment. However, which and how mRNAs are selected into different degradation pathways and what determines the fate of any given mRNA in P-bodies re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1791iti2